Tropical Medicine and Health
Online ISSN : 1349-4147
Print ISSN : 1348-8945
ISSN-L : 1348-8945

This article has now been updated. Please use the final version.

Population based cohort study for Pediatric Infectious Diseases research in Vietnam
Lay-Myint Yoshida, Motoi Suzuki, Vu Dinh Thiem, Wolf Peter Smith, Ataru Tsuzuki, Vu Thi Thu Huong, Kensuke Takahashi, Masami Miyakawa, Nguyen Thi Hien Anh, Kiwao Watanabe, Nguyen Thu Thuy Ai, Le Huu Tho, Paul Kilgore, Hiroshi Yoshino, Michiko Toizumi, Michio Yasunami, Hiroyuki Moriuchi, Dang Duc Anh, Koya Ariyoshi
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Keywords: Population based cohort, pediatric, infectious diseases, Vietnam
JOURNAL FREE ACCESS Advance online publication

Article ID: 2014-S07

The final version of this article is now available: Vol. 42 (2014), No. 2SUPPLEMENT pp. S47-S58
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Abstract
A population-based cohort study on pediatric infectious diseases was established at Khanh Hoa Province, central Vietnam in 2006, to determine the etiology and risk factors for severe pediatric infectious diseases (SPID) such as acute respiratory infection (ARI), diarrhea and dengue which are the major causes of under 5 mortality. A population census survey was conducted in Nha-Trang and Ninh-Hoa to collect demographic, social-behavioral data and disease burden on SPID. The study site covered a population of 353,525 residing in 75,826 households with 24,781 children less than 5 years. Hospital databases from two hospitals covering the region were obtained. Linking the census and hospital databases, we were able to investigate on a variety of SPID such as environmental tobacco smoking exposure and increased risked of pediatric pneumonia hospitalization, population density, water supply and risk of dengue fever and animal livestock and risk of hospitalized diarrhea. To determine incidence, viral etiology and risk factors for pediatric ARI/pneumonia, we setup a population based prospective hospitalized Pediatric ARI surveillance at Khanh Hoa General Hospital, Nha-Trang in February 2007. The study has revealed RSV, rhinovirus and influenza A as major viral pathogens, role of multiple viral infection and its interaction with bacteria in the development of pneumonia. In addition, we are also conducting a birth cohort study to investigate the incidence of congenital infection and its impact on physical-neurological development, and role of host genetic polymorphism on SPID hospitalization in Vietnam. Population mobility, high cost of regular census update and low mortality are the challenges.
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